キハラ ノブヒロ   Kihara Nobuhiro
  木原 伸浩
   所属   神奈川大学  理学部 化学科
   職種   教授
言語種別 英語
発行・発表の年月 1999/11
形態種別 学術雑誌
査読 査読あり
標題 Efficient Radical Oxygenation of alpha-Iodocarboxylic Acid Derivatives,
執筆形態 共著
掲載誌名 Org. Lett.
巻・号・頁 1(9),pp.1419-1422
著者・共著者 Nobuhiro Kihara, Cyril Ollivier, and Philippe Renaud
概要 Treatment of α-iodocarboxylic acid derivs. with 2 equiv of triethylborane under an oxygen atm. gives the corresponding α-hydroxy acid derivs. This method is based on an iodine atom transfer from the Et radical, generated by the reaction of triethylborane and oxygen, with the α-iodocarbonyl compd. It offers several advantages over classical ionic substitution reactions: no elimination product is obsd., tertiary iodides are efficiently converted to alcs., and finally, this one-step procedure works with substrates sensitive to nucleophiles.
DOI 10.1021/ol990971n
ISSN 1523-7060