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イブカ アキコ
Ibuka Akiko 井深 章子 所属 神奈川大学 化学生命学部 生命機能学科 神奈川大学大学院 理学研究科 理学専攻（生物科学領域） 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2012/07 |
| 形態種別 | 学術雑誌 |
| 査読 | 査読あり |
| 標題 | Novel Angiotensin I-Converting Enzyme Inhibitory Peptides Found in a Thermolysin-Treated Elastin with Antihypertensive Activity |
| 執筆形態 | 共著 |
| 掲載誌名 | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY |
| 掲載区分 | 国外 |
| 出版社・発行元 | TAYLOR&FRANCIS LTD |
| 巻・号・頁 | 76(7),pp.1329-1333 |
| 著者・共著者 | Yuko Sato,Tsudoi Toyoda,Akiko Shimizu-Ibuka,Tomoko Tamura,Kazuo Kobayashi-Hattori,Takemichi Nakamura,Soichi Arai,Kiyoshi Mura |
| 概要 | Angiotensin I-converting enzyme (ACE) inhibitory activity was generated from elastin by hydrolyzing with thermolysin. We confirmed the antihypertensive activity of the elastin hydrolysate in vivo by feeding spontaneously hypertensive rats. We identified novel ACE inhibitory peptides, VGHyp, VVPG and VYPGG, in the elastin hydrolysate by using a protein sequencer and quadrupole linear ion trap (QIT)-LC/MS/MS. VYPGG had the highest IC50 value of 244 mu M against ACE and may have potential use as a functional food. |
| DOI | 10.1271/bbb.120083 |
| ISSN | 09168451 |
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