研究者情報 | 神奈川大学

イブカ　アキコ Ibuka Akiko 井深　章子所属神奈川大学化学生命学部生命機能学科神奈川大学大学院理学研究科理学専攻（生物科学領域）職種教授
言語種別	英語
発行・発表の年月	2018/08
形態種別	学術雑誌
査読	査読あり
標題	Structural and functional analysis of miraculin-like protein fromVitis vinifera.
執筆形態	共著
掲載誌名	Biochim. Biophys. Acta Proteins Proteom.
掲載区分	国外
巻・号・頁	1866(11),pp.1125-1130
著者・共著者	Ohkura,S., Hori,M., Saitoh,K., Okuzawa,T., Okamoto,I., Furukawa,N., and Shimizu-Ibuka,A.
概要	Miraculin-like proteins (MLPs) are homologous to miraculin, a homodimeric protein with taste-modifying activity that converts sourness into sweetness. MLP from grape (vvMLP) exhibits significant homology to miraculin (61% identity). The crystal structure revealed that vvMLP has a beta-trefoil fold, similarly as other MLPs and Kunitz-type protein inhibitors. Recombinant vvMLP had inhibitory activity against trypsin, indicating that the protein can act as a moderate trypsin inhibitor.