研究者情報 | 神奈川大学

ナカダ　ノリヒデ Nakada Norihide 中田　典秀所属神奈川大学化学生命学部応用化学科神奈川大学大学院工学研究科工学専攻（応用化学領域）職種准教授
言語種別	英語
発行・発表の年月	2014
形態種別	学術雑誌
査読	査読あり
標題	Optimisation of the analysis of anti-influenza drugs in wastewater and surface water
執筆形態	共著
掲載誌名	INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
出版社・発行元	TAYLOR&FRANCIS LTD
巻・号・頁	94(9),pp.853-862
著者・共著者	Takashi Azuma,Norihide Nakada,Naoyuki Yamashita,Hiroaki Tanaka
概要	We optimised the simultaneous analysis of four analytes, namely three anti-influenza drugs (oseltamivir (OS), zanamivir (ZAN) and amantadine (AMN)) and one metabolite of OS (oseltamivir carboxylate (OC)), in sewage treatment plant (STP) influent and effluent by verifying the types and conditions of solid phase extraction (SPE) appropriate for LC-MS/MS analysis. In summary, these target analytes were extracted from aqueous samples (30-50 mL) by using strong cation-exchange SPE cartridges (500 mg adsorbent) under acidic conditions (pH 3-4). After washing of the cartridges with acidified water (pH 3.0, 3 mL) and methanol (3 mL), the analytes were eluted with a mixed solvent (2 mL) of 10% (v/v) triethylamine in a 1:1 (v/v) mixture of acetone and water. Application of this technique to the target compounds should yield a comprehensive understanding of the occurrence and fate of anti-influenza drugs in the water environment.
DOI	10.1080/03067319.2014.921290
ISSN	03067319