研究者情報 | 神奈川大学

ヤマシタ　ユウジ Yamashita Yuji 山下　裕司所属神奈川大学化学生命学部生命機能学科神奈川大学大学院工学研究科工学専攻（生命機能工学領域）職種教授
言語種別	日本語
発行・発表の年月	2020
形態種別	学術雑誌
査読	査読あり
標題	複製老化した真皮線維芽細胞の黄色化とカルボニル化
執筆形態	共著
掲載誌名	日本香粧品学会誌
掲載区分	国内
出版社・発行元	日本香粧品学会
巻・号・頁	44(2),92-98頁
担当範囲	ディスカッション、執筆内容の確認・修正
著者・共著者	江口琴音，吉本聖，吉田萌生，柳大樹，八木政幸，山下裕司，平尾哲二，市橋正光，安藤秀哉
概要	The yellowish coloration of the aged skin is generally known to be caused by the yellowing of dermal extracellular matrix such as collagen. We, however, found that cultured dermal fibroblasts themselves became yellowish color after long-term culture. In this study, we investigated the mechanisms of yellowish coloration of the replicatively senescent dermal fibroblasts. Based on our results, we speculate that the carbonylation of dermal fibroblasts may be related to the yellowing of aged skin similar to the carbonylated dermal extracellular matrix. Further, it was expected that inhibition of ROS could restore the yellowish color to the previous color in yellowed cells, even in the skin.