研究者情報 | 神奈川大学

スズキ　ケンタロウ Suzuki Kentaro 鈴木　健太郎所属神奈川大学理学部理学科神奈川大学大学院理学研究科理学専攻（化学領域）職種教授
言語種別	英語
発行・発表の年月	2019/05
形態種別	学術雑誌
査読	査読あり
標題	DNA Length-dependent Division of a Giant Vesicle-based Model Protocell
執筆形態	共著
掲載誌名	Sci. Rep.
掲載区分	国外
巻・号・頁	9,pp.6916
著者・共著者	Muneyuki Matsuo, Yumi Kan, Kensuke Kurihara, Takehiro Jimbo, Masayuki Imai, Taro Toyota, Yuiko Hirata, Kentaro Suzuki, Tadashi Sugawara
概要	DNA is an essential carrier of sequence-based genetic information for all life today. However, the chemical and physical properties of DNA may also affect the structure and dynamics of a vesicle-based model protocell in which it is encapsulated. To test these effects, we constructed a polyethylene glycolgrafted giant vesicle system capable of undergoing growth and division. The system incorporates a specific interaction between DNA and lipophilic catalysts as well as components of PCR. We found that vesicle division depends on the length of the encapsulated DNA, and the self-assembly of an internal supramolecular catalyst possibly leads to the direct causal relationship between DNA length and the capacity of the vesicle to self-reproduce. These results may help elucidate how nucleic acids could have functioned in the division of prebiotic protocells.
DOI	10.1038/s41598-019-43367-4
PermalinkURL	https://www.nature.com/articles/s41598-019-43367-4