イワクラ イズミ   Iwakura Izumi
  岩倉 いずみ
   所属   神奈川大学  化学生命学部 応用化学科
    神奈川大学大学院  工学研究科 工学専攻(応用化学領域)
   職種   教授
言語種別 英語
発行・発表の年月 2003/10
形態種別 学術雑誌
査読 査読あり
標題 Enantioselective Borodeuteride Reduction of Aldimines Catalyzed by Cobalt Complexes: Preparation of Optically Active Deuterated Primary Amines.
執筆形態 共著
掲載誌名 Organic Letters
掲載区分国外
巻・号・頁 5(20),pp.3555-3558
著者・共著者 Daichi Miyazaki, Kohei Nomura, Tatsuya Yamashita, Izumi Iwakura, Taketo Ikeno, Tohru Yamada
概要 The enantioselective borodeuteride reduction catalyzed by optically active β-ketoiminato cobalt complexes was applied to N-(di(o-tolyl)phosphinyl)aldimines to afford the corresponding optically active deuterated primary amines in high yields with high enantiomeric excesses after simple deprotection. The present deuteride reduction of aldimines is in the opposite sense of the enantioselective for the previously reported borohydride reduction of ketones or diphenylphosphinyl aldimines. The stereochemical course in these enantioselective reductions is discussed. Hot Article
DOI https://doi.org/10.1021/ol0349920
researchmap用URL https://pubs.acs.org/doi/10.1021/ol0349920