研究者情報 | 神奈川大学

スズキ　ケンタロウ Suzuki Kentaro 鈴木　健太郎所属神奈川大学理学部理学科神奈川大学大学院理学研究科理学専攻（化学領域）職種教授
言語種別	英語
発行・発表の年月	2019/04
形態種別	学術雑誌
査読	査読あり
標題	A Sustainable Self-reproducing Liposome Consisting of a Synthetic Phospholipid
執筆形態	共著
掲載誌名	Chem. Phys. Lipids
掲載区分	国外
巻・号・頁	222,pp.1-7
著者・共著者	Muneyuki Matsuoa, Shota Ohyama, Kotoba Sakurai, Taro Toyotaa, Kentaro Suzuki, Tadashi Sugawara
概要	A novel phosphoric membrane lipid (phospholipid) bearing an oleyl group as one of the hydrophobic chains formed a liposome with a thin lamella in water. Since the anionic membrane of pre-existing liposomes acted as a catalytic surface in phosphate buffer, membrane lipids could be generated from their precursor in an autocatalytic manner without the inclusion of catalytic amphiphiles in the liposome. The morphological changes of this anionic liposome were monitored both by flow cytometry and optical microscopy, and it was found that the liposomes deformed into a budding shape, followed by division, after the addition of a membrane precursor. Hence, this anionic monocomponent liposome could be regarded as a sustainable self-reproducing system. This liposome was also able to provide a reaction cavity for enzymatic reactions, such as DNA amplification by a polymerase chain reaction.
DOI	10.1016/j.chemphyslip.2019.04.007
PermalinkURL	https://www.sciencedirect.com/science/article/pii/S0009308418302627