スズキ ケンタロウ   Suzuki Kentaro
  鈴木 健太郎
   所属   神奈川大学  理学部 理学科
    神奈川大学大学院  理学研究科 理学専攻(化学領域)
   職種   教授
言語種別 英語
発行・発表の年月 2019/05
形態種別 学術雑誌
査読 査読あり
標題 DNA Length-dependent Division of a Giant Vesicle-based Model Protocell
執筆形態 共著
掲載誌名 Sci. Rep.
掲載区分国外
巻・号・頁 9,pp.6916
著者・共著者 Muneyuki Matsuo, Yumi Kan, Kensuke Kurihara, Takehiro Jimbo, Masayuki Imai, Taro Toyota, Yuiko Hirata, Kentaro Suzuki, Tadashi Sugawara
概要 DNA is an essential carrier of sequence-based genetic information for all life today. However, the chemical and physical properties of DNA may also affect the structure and dynamics of a vesicle-based model protocell in which it is encapsulated. To test these effects, we constructed a polyethylene glycolgrafted giant vesicle system capable of undergoing growth and division. The system incorporates a specific interaction between DNA and lipophilic catalysts as well as components of PCR. We found that vesicle division depends on the length of the encapsulated DNA, and the self-assembly of an internal supramolecular catalyst possibly leads to the direct causal relationship between DNA length and the capacity of the vesicle to self-reproduce. These results may help elucidate how nucleic acids could have functioned in the division of prebiotic protocells.
DOI 10.1038/s41598-019-43367-4
PermalinkURL https://www.nature.com/articles/s41598-019-43367-4