イケハラ タカユキ   Ikehara Takayuki
  池原 飛之
   所属   神奈川大学  工学部 物質生命化学科
    神奈川大学大学院  工学研究科 工学専攻(応用化学領域)
   職種   教授
言語種別 日本語
発行・発表の年月 2007/12
形態種別 学術雑誌
査読 査読あり
標題 Thermal properties and microstructures of methylated polyrotaxane solutions
執筆形態 共著
掲載誌名 Current Drug Discovery Technologies
巻・号・頁 4(4),275-281頁
著者・共著者 Kataoka, Toshiyuki; Kidowaki, Masatoshi; Zhao, Changming; Araki, Jun; Ikehara, Takayuki; Ito, Kohzo
概要 Aq. solns. of polyrotaxanes consisting of poly(ethylene glycol) and methylated alpha-cyclodextrins (alpha-CD) were studied by means of differential scanning calorimetry (DSC), dynamic light scattering, and X-ray diffraction in order to investigate the effect of the degree of methylation on thermoresponsive behavior. Polyrotaxanes with a degree of methylation higher than 50% had a lower crit. soln. temp. (LCST) and showed reversible assocns. and dissocns. in water. In the transmittance measurements, the cloud point of methylated polyrotaxanes (MePR) shifted to a lower temp. with an increase in the degree of methylation. The heating curve obtained by DSC for the nearly permethylated polyrotaxane showed one broad endothermic peak that was assocd. with the microcrystn. of methylated CDs by hydrophobic interactions. On the other hand, the DSC profiles for partially methylated polyrotaxanes had several endothermic peaks, indicating multiple phase transitions of the MePR solns. The results imply that the thermal properties of the MePR-water system are significantly affected by not only the Me groups on alpha-CDs but also by the remaining hydroxyl groups.